The Buffalo Bills (6-5) face the New England Patriots (2-9) on Thursday Night Football as 3.5-point road favorites. This AFC East rivalry game has major playoff implications for Buffalo as they look to keep pace with Miami in the division.

The Bills enter on a two-game win streak after consecutive victories in Detroit over the Browns and Lions. However, Josh Allen and the offense must improve their red zone efficiency and limit turnovers against New England's disciplined defense.

The Patriots are coming off a Thanksgiving night loss to Minnesota where their defense struggled against the pass. They'll need another strong performance from their ground game to control possession and limit Buffalo's offensive opportunities.

Key Factors:

• Bills must scheme ways to get Stefon Diggs and Dawson Knox open against tight Patriots coverage
• Mac Jones and the Patriots passing attack needs to maintain drives through Hunter Henry and Rhamondre Stevenson
• Cold weather conditions in Foxborough could impact both teams' aerial attacks
• Bills red zone execution will be crucial against Patriots' defensive discipline
• Patriots' ability to establish the run and control time of possession could keep it close

The Bills' superior offensive firepower makes them favorites, but a Thursday night road game in New England presents unique challenges. Buffalo will need better situational execution to avoid an upset against their division rivals.

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