NFL Thanksgiving Day 2021 features three exciting matchups with betting opportunities. Here's a detailed analysis and moneyline picks for each game:

Bears @ Lions (12:30 PM ET, FOX)

• Lions showing improvement despite winless record
• Bears dealing with coaching drama and injuries
• No Justin Fields or Jared Goff
• Key injuries: Khalil Mack (out), Akiem Hicks (questionable) Pick: Lions ML (+135)

Raiders @ Cowboys (4:30 PM ET, CBS)

• Cowboys looking to bounce back from Chiefs loss
• Raiders on two-game losing streak
• Vegas lacking offensive weapons without Ruggs
• Dak Prescott expected to improve Pick: Cowboys ML (-335)

Bills @ Saints (8:20 PM ET, NBC)

• Bills struggling with offensive consistency
• Saints limited offensively with QB issues
• Alvin Kamara key for Saints offense
• Sean Payton factor keeps spread risky Pick: Bills ML (-278)

Parlay Opportunity: Bills + Cowboys + Lions ML parlay offers +315 odds

Note: All games offer solid moneyline value, but consider the risk of parlaying all three selections together.

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