The San Francisco Giants (25-16) face the Cincinnati Reds (19-20) in game two of their four-game series at Great American Ballpark, with first pitch at 6:40 pm ET. The Giants won the opener 6-3 behind Logan Webb's six scoreless innings and three team home runs.

The Reds enter as -126 favorites, with the Giants at +108. The runline is San Francisco +1.5 and the over/under total is 8 runs.

Pitching Matchup:

• Giants: Anthony DeSclafani (3-1, 2.14 ERA) faces his former team
• Reds: Luis Castillo (1-5, 7.71 ERA) looks to turn around his struggles

Key Stats:

• Reds lead MLB in runs per game (5.39)
• Giants rank 2nd in runs allowed (3.50)
• Giants are 7-3 in their last 10 games
• Reds are 5-5 in their last 10 games

Players to Watch:

• Giants: Brandon Crawford leads team with 9 HR and 22 RBI
• Reds: Nick Castellanos batting .331/.391/.627 with 10 HR
• Eugenio Suarez heating up: .276/.313/.552 with 2 HR last week

The Giants aim to extend their NL-best record while the Reds look to even the series behind their struggling ace Castillo. DeSclafani's return to Cincinnati adds intrigue to this compelling pitching matchup between NL contenders.

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