March Madness Day 2 Betting Guide: Round of 64 Best Picks and Predictions

March Madness Day 2 Betting Guide: Round of 64 Best Picks and Predictions

By Michael Peterson

March 15, 2025 at 07:19 AM

Currently on a 9-5 hot streak since March Madness began, here are detailed betting previews for Day Two of the Round of 64:

#7 Ohio State (+0.5) vs #10 Loyola Chicago

  • Ohio State likely to win with healthy Zed Key and Kyle Young
  • Playing in Pittsburgh gives Buckeyes home court advantage
  • EJ Lidell matchup advantage favors OSU
  • 66% of public money on Loyola suggests value on OSU Pick: Ohio State +0.5

#6 Texas (-1) vs #11 Virginia Tech

  • Texas has elite defense per KenPom metrics
  • Virginia Tech's offensive numbers inflated by weak ACC
  • Chris Beard's "no middle" defense difficult to prepare for
  • Tech was bid stealer, didn't show consistency all season Pick: Texas -1

Michigan State vs Davidson (O/U 140)

  • Davidson's offense struggled in A10 Championship
  • MSU defense stronger than Davidson's conference opponents
  • Spartans offense inconsistent, averaging under 80 points
  • Low-scoring defensive battle expected Pick: Under 140

#6 LSU vs #11 Iowa State (+4, O/U 126)

  • LSU dealing with coaching change before tournament
  • Iowa State's Brockington can take over games
  • Both teams top-10 in defense
  • Iowa State poised for offensive breakout Picks: Iowa State +4, Over 126, Iowa State ML +160 (0.5u)

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