March Madness First-Round Betting Guide: 3 Underdog Picks with High Value Potential

March Madness First-Round Betting Guide: 3 Underdog Picks with High Value Potential

By Michael Peterson

March 22, 2025 at 12:52 PM

The 2025 NCAA Tournament bracket release reveals several promising first-round underdog opportunities worth targeting early.

Man wearing blue shirt

Man wearing blue shirt

Drake (+5.5) vs Missouri

  • Drake's defense ranks 8th nationally over the last three games
  • Missouri's 5th-ranked offense faces tough defensive matchup
  • Line opened higher than expected at +5.5
  • Strong potential for straight-up win
  • Best odds: DraftKings (-102)

Yale (+7.5) vs Texas A&M

  • Yale shoots 37% from three-point range
  • Texas A&M struggles defending three-pointers
  • Slow-paced game favors Yale's style
  • Spread too wide for teams' relative strength
  • Best odds: FanDuel (-110)

Liberty (+5.5) vs Oregon

  • Nation's best effective field goal percentage
  • Slow pace will disrupt Oregon's 76 PPG offense
  • Unconventional style makes preparation difficult
  • Strong upset potential straight-up
  • Best odds: DraftKings (-110)

All three underdogs show legitimate potential for not just covering but winning outright. Early line movement suggests acting quickly on these values before odds adjust.

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John Hyslop smiling at camera

John Hyslop smiling at camera

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