MLB Home Run Props & Parlay Guide: +13056 Odds for Monday's Best HR Bets (April 21)

By Michael Peterson

April 28, 2025 at 09:07 AM

Today's top MLB home run betting picks combine for a +13056 parlay opportunity, featuring three power hitters in favorable matchups.

Pete Alonso celebrates after a hit

Pete Alonso celebrates after a hit

Betting Strategy: Spread 0.25 units across individual bets and parlay:

  • Three straight bets (0.25 units each)
  • One parlay combining all three (0.25 units)
  • Total risk: 1 unit

Manny Machado (+420) vs Detroit Tigers

  • Consistently hitting balls 110+ MPH
  • Faces Keider Montero who's allowed 3 HRs in 5 innings
  • Strong matchup against Montero's pitch mix

Pete Alonso (+450) vs Phillies

  • 4 hits of 104+ MPH in last 4 games
  • Strong history vs Aaron Nola (6 HRs in 57 at-bats)
  • Excelling against four-seam fastballs this season

Marcell Ozuna (+360) vs Erick Fedde

  • Recent power surge with multiple 110+ MPH exits
  • 5 hits of 104+ MPH in last 2 games
  • Already has 2 career HRs against Fedde
  • Historically successful against Fedde's sweeper

Combined parlay odds: +13056

John Hyslop smiling at camera

John Hyslop smiling at camera

Betting odds via FanDuel as of April 21. Must be 21+. If you have a gambling problem, call 1-800-GAMBLER.

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