The Indianapolis Colts (8-6) face the Arizona Cardinals (10-4) in a crucial Week 16 matchup on Christmas night in Glendale. The Cardinals enter as 1-point home favorites despite recent struggles.

The Colts come in hot, winning 5 of their last 6 games, including a convincing 27-17 victory over the Patriots last week. Running back Jonathan Taylor continues his dominant season with over 1,500 rushing yards, while quarterback Carson Wentz has limited turnovers with just 6 interceptions.

The Cardinals are looking to bounce back after a shocking loss to the Detroit Lions. Their defense has allowed 30+ points in consecutive games, while the offense managed just 12 points against Detroit. Kyler Murray and the offense need to regain their early-season form.

Key Factors:

• Colts' running game and time of possession control will be crucial
• Cardinals' defense must improve against the run after recent struggles
• Both teams have playoff implications riding on this matchup

The game will likely come down to whether Arizona's defense can contain Taylor and the Colts' physical rushing attack, while their offense tries to rediscover its rhythm against a confident Indianapolis team.

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