Ohio State Buckeyes 2022 Betting Guide: Top Preseason Wagers and Championship Odds

Ohio State Buckeyes 2022 Betting Guide: Top Preseason Wagers and Championship Odds

By Michael Peterson

February 25, 2025 at 09:48 AM

After missing the College Football Playoff in 2021 despite an 11-2 record, the Ohio State Buckeyes enter 2022 with championship aspirations. Their playoff hopes were dashed last season after a 42-27 loss to rival Michigan, though they ended on a high note with a 48-45 Rose Bowl victory over Utah.

Key Betting Opportunities for 2022:

Ohio State -14.5 vs Notre Dame (-110)

  • Season opener in Columbus with College Gameday present
  • Buckeyes' experience and talent advantage makes the spread attractive
  • Home field advantage will be significant

National Championship Odds (+250)

  • Third-best odds behind Alabama and Georgia
  • Return of sophomore QB CJ Stroud bolsters chances
  • New defensive coaching staff addresses 2021 weaknesses
  • 6 of 9 bowl-eligible opponents at home, including Michigan

CJ Stroud Heisman Trophy (+175)

  • Current Heisman favorite after impressive 2021 campaign
  • 4,435 yards, 44 TDs, 72% completion rate last season
  • Ranked 5th in yards, 3rd in TDs, 1st in QBR
  • Returns top target Jaxson Smith-Njigba
  • Additional weapons in Marvin Harrison Jr. and Julian Fleming

A strengthened defense combined with Stroud's development and a favorable home schedule positions Ohio State as a serious contender for both conference and national titles in 2022.

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