
Top 3 MLB Parlay Picks for September 22: Yankees, Brewers, Guardians
Looking for a strong MLB parlay bet for September 22? Here's a recommended three-team combination with high potential value:
Milwaukee Brewers (-150) vs. Cincinnati Reds
- Brewers' ace Brandon Woodruff (11-4, 3.26 ERA) faces struggling Hunter Greene (4-12)
- Milwaukee fighting for Wild Card spot, 2.5 games behind Philadelphia
- Strong pitching matchup favors Brewers early
New York Yankees (-170) vs. Boston Red Sox
- Yankees coming off 14-2 win against Pirates
- Aaron Judge at 60 home runs and counting
- Yankees lead Red Sox by 97 home runs this season
- Yankees have scored 78 more runs than Boston in 2022
Cleveland Guardians (-135) vs. Chicago White Sox
- Shane Bieber (11-8) starting for Cleveland
- Bieber ranks top 15 in ERA, strikeouts, and WHIP
- Guardians lead season series 11-7
- Cleveland looking to extend 6-game AL Central lead
- White Sox have negative run differential
Key Stats:
- Combined odds: +400 (approximate)
- All three teams in playoff contention
- Strong pitching matchups favor all selections
- Offensive advantages present in each game
This parlay combines strong pitching, playoff motivation, and favorable matchups for solid betting value.

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