Top 3 MLB Parlay Picks for September 22: Yankees, Brewers, Guardians

Top 3 MLB Parlay Picks for September 22: Yankees, Brewers, Guardians

By Michael Peterson

March 17, 2025 at 05:42 PM

Looking for a strong MLB parlay bet for September 22? Here's a recommended three-team combination with high potential value:

Milwaukee Brewers (-150) vs. Cincinnati Reds

  • Brewers' ace Brandon Woodruff (11-4, 3.26 ERA) faces struggling Hunter Greene (4-12)
  • Milwaukee fighting for Wild Card spot, 2.5 games behind Philadelphia
  • Strong pitching matchup favors Brewers early

New York Yankees (-170) vs. Boston Red Sox

  • Yankees coming off 14-2 win against Pirates
  • Aaron Judge at 60 home runs and counting
  • Yankees lead Red Sox by 97 home runs this season
  • Yankees have scored 78 more runs than Boston in 2022

Cleveland Guardians (-135) vs. Chicago White Sox

  • Shane Bieber (11-8) starting for Cleveland
  • Bieber ranks top 15 in ERA, strikeouts, and WHIP
  • Guardians lead season series 11-7
  • Cleveland looking to extend 6-game AL Central lead
  • White Sox have negative run differential

Key Stats:

  • Combined odds: +400 (approximate)
  • All three teams in playoff contention
  • Strong pitching matchups favor all selections
  • Offensive advantages present in each game

This parlay combines strong pitching, playoff motivation, and favorable matchups for solid betting value.

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