The South Region of the 2022 NCAA Tournament features three top-five seeds advancing to the Sweet 16, with Michigan being the lone lower seed looking to play spoiler. Here's a comprehensive breakdown of the matchups and predictions:

Villanova (-5.0) vs Michigan

• Villanova's efficient offense faces Michigan's inside scoring approach
• Both teams excel defensively
• Prediction: Villanova to cover the spread with strong offensive execution

Arizona (-1.5) vs Houston

• Contrasting styles: Arizona's high-scoring offense (80 PPG) vs Houston's defensive focus
• Arizona has athletic advantage
• Prediction: Arizona to win and cover the slim spread

Regional Final Prediction

• Anticipated matchup: Arizona vs Villanova
• Arizona's explosive offense expected to overwhelm Villanova
• Final prediction: Arizona advances to Final Four

Key Factors:

• Arizona's offensive firepower averaging 80 points per game
• Villanova's efficient offensive system
• Houston's defensive prowess
• Michigan's surprising tournament run

The number one seed Arizona Wildcats are favored to emerge from the South Region and advance to the Final Four, backed by their superior offensive capabilities and athletic advantage over their remaining opponents.

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