MLS Betting Guide: Columbus Crew Host Nashville SC in Eastern Conference Clash

MLS Betting Guide: Columbus Crew Host Nashville SC in Eastern Conference Clash

By Michael Peterson

February 28, 2025 at 11:51 PM

The Columbus Crew host Nashville SC at Lower.com Field in a crucial Eastern Conference matchup on Wednesday at 7:30 p.m. ET. Both teams aim to break into the top four after weekend victories during their three-game week.

Columbus holds a perfect 2-0-0 record against Nashville, winning both previous matches 2-0. The Crew eliminated Nashville in the 2020 MLS Cup Playoffs East Conference Semifinals with two extra-time goals.

Team Updates

Columbus Crew

  • Lucas Zelarayan set a franchise record with his fourth free-kick goal this season in Saturday's 2-1 win over NYCFC
  • Eloy Room returns in goal after Curacao's Gold Cup exit
  • Harrison Afful back from suspension
  • Missing: Gyasi Zardes, Liam Fraser, Kevin Molina, Derrick Etienne Jr. (Gold Cup duty)
  • One loss in last eight games but only one win in last five
  • Strong home record: 18-1-2 in last 21 matches

Nashville SC

  • Coming off 5-1 win vs Chicago Fire
  • Hany Mukhtar scored hat-trick in six minutes
  • Missing: Walker Zimmerman, Alistair Johnston (Gold Cup duty)
  • Unbeaten in 15 of last 16 matches
  • Road record: 0-1-2 in three away matches

Betting Lines

  • Columbus ML: +165 (-0.5, +135)
  • Nashville ML: +175 (-0.5, -145)
  • Draw: +235
  • Total Goals 2.5: Over -115, Under -105
  • First to Score: Columbus +100, Nashville -105, No Goals +600

The Crew's set-piece threat through Zelarayan and strong home form make them slight favorites, especially with their perfect record at their new stadium and 11 goals in their last five home games.

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