Clemson vs Louisville ACC Semis: Odds, Props & How to Bet This Battle of Top-15 Teams

Clemson vs Louisville ACC Semis: Odds, Props & How to Bet This Battle of Top-15 Teams

By Michael Peterson

March 21, 2025 at 01:36 AM

The #10 Clemson Tigers (27-5) face the #13 Louisville Cardinals (26-6) in the ACC Tournament semifinal, with Clemson entering as 1-point favorites. Both teams boast impressive 18-2 conference records and recent hot streaks - Louisville has just one loss in their last 21 games, while Clemson has two in their last 20.

College players in white uniforms

College players in white uniforms

Key Game Information:

  • Time: 9:30pm ET
  • Location: Spectrum Center, Charlotte, NC
  • TV: ESPN
  • Spread: Clemson -1
  • Total: 141.5
  • Moneyline: Clemson -120, Louisville +100

Recent Form:

  • Louisville: Won 10 straight (6-4 ATS), including a narrow 75-73 win over Stanford
  • Clemson: Won 9 straight, coming off a season-low scoring output in 57-54 win vs SMU

Key Player Props:

  • Chucky Hepburn (LOU): 17.5 points, 5.5 assists
  • Terrance Edwards (LOU): 17.5 points
  • Chase Hunter (CLEM): 15.5 points
  • Ian Schieffelin (CLEM): 8.5 rebounds

Team Comparisons:

  • KenPom Rankings: Clemson #19, Louisville #25
  • Offensive Efficiency: Clemson #21, Louisville #27
  • Defensive Efficiency: Clemson #17, Louisville #23
  • Scoring: Louisville 79.2 PPG, Clemson 76.4 PPG
  • Defense: Clemson 65.3 PPG allowed, Louisville 68.7 PPG allowed

Previous Meeting: Louisville won 74-64 behind J'Vonne Hadley's 32 points and 10 rebounds. The Cardinals' advantage at the free throw line (16-20 vs 4-5) proved decisive.

The Pick: Clemson -1 (-112) Reasoning: Clemson's ACC-best 17-9 ATS record as favorites and strong defensive metrics give them a slight edge in what projects to be a closely contested game.

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